Publications on Complex Systems / Systems Biology in Acute Illness

  • Neugebauer E, Rixen D, Raum M, Schafer U. Thirty years of anti-mediator treatment in sepsis and septic shock--what have we learned?(PubMed Link)

  • Kirschner, D. Dynamics of co-infection with M. Tuberculosis and HIV-1. (PubMed Link)

  • Seely AJ, Christou NV. Multiple organ dysfunction syndrome: exploring the paradigm of complex nonlinear systems. (PubMed Link)

  • Buchman TG, Cobb JP, Lapedes AS, Kepler TB. Complex systems analysis: a tool for shock research. (PubMed Link)

  • Neugebauer EA, Willy C, Sauerland S. Complexity and non-linearity in shock research: reductionism or synthesis? (PubMed Link)

  • Wigginton J.E., Kirschner, D. A model to predict cell-mediated immune regulatory mechanisms during human infection with Mycobacterium tuberculosis. (PubMed Link)

  • Ellenby, M. S., McNames, J., Lai, S., McDonald, B. A., Krieger, D., Sclabassi, R. J., Goldstein B. Uncoupling and recoupling of autonomic regulation of the heart beat in pediatric septic shock. (PubMed Link)

  • Hlavacek, W. S., Redondo, A., Metzger, H., Wofsy, C., Goldstein, B. Kinetic proofreading models for cell signaling predict ways to escape kinetic proofreading. (PubMed Link)

  • Tjardes T, Neugebauer E. Sepsis research in the next millennium: concentrate on the software rather than the hardware. (PubMed Link)

  • An, G. Agent-based computer simulation and SIRS: building a bridge between basic science and clinical trials. (PubMed Link)

  • Buchman, T.G. The community of the self. (PubMed Link)

  • Chinnaiyan AM, Huber-Lang M, Kumar-Sinha C, Barrette TR, Shankar-Sinha S, Sarma VJ, Padgaonkar, VA, Ward PA. Molecular signatures of sepsis: multiorgan gene expression profiles of systemic inflammation. (PubMed Link)

  • Cobb JP, Laramie JM, Stormo GD, Morrissey JJ, Shannon WD, Qiu Y, Karl IE, Buchman TG, Hotchkiss RS. Sepsis gene expression profiling: murine splenic compared with hepatic responses determined by using complementary DNA microarrays. (PubMed Link)

  • Ellenby MS, McNames J, Lai S, McDonald BA, Krieger D, Sclabassi RJ, Goldstein B. Uncoupling and recoupling of autonomic regulation of the heart beat in pediatric septic shock. (PubMed Link)

  • Cameron RJ, Sleigh JW. Chaotic sepsis and the magic bullet. (PubMed Link)
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  • Janes KA, Albeck JG, Peng LX, Sorger PK, Lauffenburger DA, Yaffe MB. A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis. (PubMed Link)

  • Goldstein, B., McNames, J., McDonald, B. A., Ellenby, M., Lai, S., Sun, Z., Krieger, D., Sclabassi, R. J. Physiologic data acquisition system and database for the study of disease dynamics in the intensive care unit. (PubMed Link)

  • Neugebauer E, Tjardes T and the Multidisciplinary Working Group on Complexity, New Approaches to Shock and Trauma Research: Learning from Multidisciplinary Exchange (PubMed Link)

  • Goldstein B., Faeder J.R., Hlavacek W.S. Mathematical and computational models of immune-receptor signalling. (PubMed Link)

  • Kumar R, Clermont, G, Vodovotz, Y, Chow CC. The dynamics of acute inflammation. J.Theoretical Biol. 2004. (In Press)

  • An, G. In-silico experiments of existing and hypothetical cytokine-directed clinical trials using agent based modeling. Crit Care Med. 2004. (In Press)

  • Vodovotz Y., Clermont G., Chow C., An G. Mathematical models of the acute inflammatory response. Curr.Opin.Crit Care 2004.(In Press)

  • Clermont, G., Chow, C. C., Constantine, G. M., Vodovotz, Y., Bartels, J. Mathematical and Statistical Modeling of Acute Inflammation. Proc.Internatl.Fed.Classific.Soc. 2004.(In Press)

  • Vodovotz, Y., Chow, C. C., Bartels, J., Lagoa, C., Kumar, R., Day, J., Rubin, J., Constantine, G., Billiar, T. R., Fink, M. P., Clermont, G. In silico models of acute inflammation in animals. Shock 2004.(In Press)

  • Vodovotz, Y., Kim, P., Bagci, E. Z., Ermentrout, G. B., Chow, C. C., Bahar, I., Billiar T. R.. Inflammatory modulation of hepatocyte apoptosis by nitric oxide: in vivo, in vitro, and in silico studies. Curr.Mol.Med. 2004.(In Press)

  • Clermont, G., Bartels, J., Kumar, R.; Constantine, G., Vodovotz, Y., Chow, C. In silico design of clinical trials: a method coming of age. Crit Care Med. 2004.(In Press)

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