4th International Conference on Complexity in Acute Illness

Final Program

As of September 16, 2005

Thursday, Sep 29, 2005

	9:00 AM	WELCOME TO WORKSHOP PARTICIPANTS E. Neugebauer

	09:15 - 10:30 AM	TUTORIAL ON DYNAMICS R. Seydel

	10:30 - 12:30 AM	DATA AND FORMAT NEEDED FOR MODELING - Expectations from Modelers to Bio Scientists G. An (USA) J. Bartels (USA) R. Brause (Germany) G. B. Ermentrout (USA) C. A. Hunt (USA) R. Lefering (Germany) R. Seydel (Germany)

01:30 - 06:00 PM

Parallel WORKSHOP I

EVIDENCE BASED MODELING: DATA QUALITY

Moderators: E. Neugebauer (Germany), G. Clermont (USA)

Secretary: G. Grass (Germany)

Data Quality Assessment

(a) Clinical Data:	Immunmonitoring Outcome	A. Nierhaus (Germany) J. Marshall (Canada)

(b) Experimental Data:	Cellular Models	Y. Vodovotz (USA),
(b) Experimental Data:	Animal Models	H. Redl (AUSTRIA)

It is the aim of the workshop to develop recommendations which data should be included/excluded in mathematical models. The results of this workshop will be discussed on Saturday within the audience.

Thursday, Sep 29, 2005

01:30 - 06:00 PM

Parallel WORKSHOP II

MATHEMATILCAL MODELING - METHODS AND CRITICAL APPRAISAL

Moderators: G. B. Ermentrout (USA), R. Seydel (Germany)

Secretary: R. Lefering (Germany)

(a)	Differential Equations	G. B. Ermentrout (USA), R. Seydel (Germany)

(b)	Agent Based Models	G. An (USA)

(c)	Probalistic Models	S. Ta'asan (USA), R. Lefering (Germany)

(d)	Neuronal Networks	R. Brause (Germany)

(e)	Fitting Models to Data	G. Constantine, J. Bartels (USA)

(f)	Synthetic, Constructive, Selectionist Modeling Methods Relative to the Traditional Inductive Mathematical Approach	C. A. Hunt (USA)

It is the aim of this workshop to critically appraise the different approaches for their use in biological systems modeling (strength and weaknesses). The results will be discussed on Saturday within the audience.

06:00 PM

Dinner: "Kölsches Buffet"

- Free Evening -

Friday, Sep 30, 2005

09:00 - 09:30 AM

Welcome and Introduction

	E. Neugebauer (President SCAI)
	G. Clermont (Vice President SCAI)
	U. Brückner (President ESS)

09:30 - 11:00 AM	Session I World of Complexity - Successful Approaches Moderators: T. Buchman (USA), B. Bouillon (Germany)
09:30 - 10:00 AM	Numerical Weather Forecasting	U. Wesp (Germany)
10:00 - 10:30 AM	Models in Biology	T. Buchman (USA)
10:30 - 11:00 AM	Questions that need to be answered	J. Marshall (Canada)

11:00 - 11:30 AM

Coffee Break

11:30 AM - 01:00 PM	Session II Modeling Systems Biology and Variability Moderators: P. Cobb (USA), R. Seydel (Germany)
11:30 AM - 01:45 PM	Systems Biology Approaches for Sepsis and Trauma	P. Cobb (USA)
11:45 AM - 12:00 PM	Modeling Physiologic Variability	M. Costa, A. Goldberger (USA)
12:00 AM - 12:15 PM	Synthetic, Constructive, Selectionist Modeling Methods	C. A. Hunt (USA)
12:15 - 12:30 PM	Supercomputing Acute Illness - Modeling Parasitic Action	T. Witten (USA)
12:30 - 12:45 PM	Uncertainty and Variability: Complexity at the Bedside	A. J. E. Seely (Canada)
12:45 PM - 01:00 PM	Computer Simulations of Drug Effects in Mental Diseases and Sleep Disorders: from Cellular to Systemic Functions	A. Braun (Germany)

01:00 - 02:00 PM

Lunch Break

02:00 - 04:20 PM	Session III Modeling Organ Function and Dysfunction Moderators: Y. Vodovotz (USA), D. Schomburg (Germany)
02:00 - 02:20 PM	The Evolution of Complex Systems Analysis in Traumatic Brain Injury	B. Goldstein (USA)
02:20 - 02:40 PM	Development of a Species-Specific Model of Cerebral Hemodynamics	S. Daun T. Tjardes (Germany)
02:40 - 03:00 PM	Central Role of Danger Signals in Sepsis, Trauma, and Hemorrhage: Insights from Mathematical Simulations	Y. Vodovotz (USA)
03:00 - 03:20 PM	Gut-epithelial Barrier Function	G. An (USA)
03:20 - 03:40 PM	Modeling of Interleukin 1 - Signaling in Pathways	A. Hutzenthaler, T. Tjardes, J. Mueller (Germany)
03:40 - 04:00 PM	Heterogeneity of PMN's to a Homogeneous Traumatic Impact	C. Willy (Germany)
04:00 - 04:10 PM	Short communitcation (see poster):Creating Clinical Usefull In Silico Models of intracranial Pressure Dynamics	W.W. Wakeland et al. (USA)
04:10 - 04:20 PM	Short communitcation (see poster):Determinants of the Irreversibility of Hemorrhagic Shock: An Exploratory Simulation Study	S. Zenker et al. (USA)

04:20 - 04:50 PM

Coffee Break

04:50 - 06:10 PM	Session IV Academia, Industry and Complexity Moderator: T. Petzinger, S. Chang (USA)
04:50 - 05:10 PM	Launchcyte: Modeling in Business	T. Petzinger (USA)
05:10 - 05:30 PM	Insilico: Data Modeling for Systems Biologists	G. Weberndorfer (Austria)
05:30 - 05:50 PM	Immunetrics: Industry Trends for Biomarkers and a Platform for Biomarker Dicovery	S. Chang (USA)
05:50 - 06:10 PM	IBM: The Mating of Elephants - Or how the Sexes in Science Can Mate and Produce Idea Offsprings	F. Busche (USA)

07:00 PM

DINNER
Location: German Sports and Olympic Museum


	The German Sports & Olympic Museum is situated on a formal customs hall out of the 18th century in the Cologne Rhine harbour. Unique is the Rhine terrace with the view on the Severinsbridge and the river banks of Cologne Deutz. The museum itself is very special in the way that one can see original, historical sports objects such as Michael Schumacher’s Benetton-Renault and a lot more.

Saturday, Oct 1, 2005

09:00 - 10:00 AM	Session V Workshop Reports Moderator: G. An (USA)
09:00 - 09:30 AM	Workshop I: Evidence Based Modeling - Standards	E. Neugebauer (Germany), G. Clermont (USA)
09:30 - 10:00 AM	Workshop II: Mathematical Modeling - Methods and Critical Appraisal	G. B. Ermentrout (USA), R. Seydel (Germany)

10:00 - 11:30 AM

Poster Discussions and Coffee
Moderators: U. Brückner (Germany), Y. Vodovotz (USA)

11:30 - 12:00 AM

General Assembly SCAI

12:00 - 12:30 PM

Lunch Break

12:30 - 01:40 PM	Session VI Modeling Molecular Systems and Pathways Moderators: P. Cobb (USA), U.Schäfer (Germany)
12:30 - 12:45 PM	Approaches to Genomic Analysis	W. Dörfler (Germany)
12:45 - 01:00 PM	Methods for Mining and Modeling of Proteomics Data Sets - application to Hemorrhagic Shock	B. Day (USA)
01:00 - 01:15 PM	Limitations of Current Approaches	P. Cobb (USA)
01:15 - 01:30 PM	A systems biology approach to modelling metabolic networks	T. Fallisch, D. Schomburg (Germany)
01:30 - 01:40 PM	Short communitcation (see poster):Massive Blood Transfusion Induces Characteristic Monocyte mRNA Expression Patterns in Patients After Multiple Major Trauma: A Microarray Pilot Study	V. Bogner et al. (Germany)

01:50 - 03:00 PM	Session VII Clinical Applications Moderators: G. Clermont (USA), J. Marshall (Canada)
01:50 - 02:05 PM	Pathogen Dissemination in Healthcare Facilities: What to do when traditional Assumptions Fail	J.R. Hotchkiss (USA)
02:05 - 02:20 PM	Trauma Trials	M. Maegele, T. Tjardes, N. Yücel (Germany)
02:20 - 02:35 PM	Sepsis Trials	G. Clermont (USA)
02:35 - 02:50 PM	Computer Analysis and Data Integration of Organ Biochemistry Monitored bedside in the ICU	U. Ungerstedt (Sweden)
02:50 - 03:00 PM	Short communication (see poster): Predicting Disease Progression Using Dynamic Microsimulation in Pneumonia-Related Sepsis Selected Free Talk	G. Saka et al. (USA)

03:00 - 03:20 PM

Closing Session
Final Remarks
Prizes