Sponsored by
University of Pittsburgh School of Medicine
Center for Continuing Education in the Health Sciences
and the
Department of Critical Care Medicine
International Conference on Complexity in Acute Illness
November 7 - 9, 2004
Conference Room S100, Biomedical Science Tower
University of Pittsburgh
200 Lothrop Street, Pittsburgh, PA
SUNDAY, NOVEMBER 7
Session I: Modeling Approaches to Acute Inflammation
9:30 a.m. Introductory Remarks Gilles Clermont/Edmund Neugebauer
9:45 a.m. Understanding the Illness Caused by Injury Timothy R. Billiar
10:15 a.m. Multiple Organ Dysfunction from an Epithelial Russ Delude
Cell's Prospective
10:45 a.m. COFFEE BREAK
11:00 a.m. Discrete Dynamical Simulations G. Bard Ermentrout
11:30 a.m. Simulation Modeling Mark S. Roberts
12:00 p.m. LUNCH Room S123BST
Session II: Methodological and Statistical Issues in Modeling Complex Systems
1:00 p.m. Optimal Allocation of Observaions in Models Gregory M. Constantine
Defined by Dynamical Systems
1:30 p.m. Predicting Outcome in Trauma Victims Rolf Lefering
2:00 p.m. A Signal Processing Approach to Classifying Mass Milos Hauskrecht
Spectrometry Data
2:30 p.m. COFFEE BREAK
2:45 p.m. Validation and Calibration in Animals of a Yoram Vodovotz
Mathematical Model of Inflammation
3:15 p.m. Optimization Issues in Modeling John Bartels
3:45 p.m. Challenges of Global Optimization Algorithms Andrew Schaefer
4:15 p.m. Panel Discussion
4:30 p.m. SCAI MEMBERS ANNUAL MEETING
MONDAY, NOVEMBER 8
Session III: Organ Function and Dysfunction
8:30 a.m. Theories of MODS Michael Pinsky
9:00 a.m. Modeling in the Study of Irreversible Shock States Juan Puyana
9:30 a.m. Biologic Variability and Organ Function Andrew Seely
10:00 a.m. Biomedical Signal Changes in Acute Traumatic Brahm Goldstein
Brain Injury
10:30 a.m. COFFEE BREAK
10:45 a.m. Cardiac Output Variations: Modeling Controller Adam Seiver
Dysfunction
11:15 a.m. Continuous Hemofiltration: A Salutary Intervention John A. Kellum
in Acute Biological Stress?
11:45 a.m. Criteria for Inclusion of Variables in Models of Acute Edmund Neugebauer
Inflammation of Relevance to Trauma and Sepsis
12:15 p.m. LUNCH Room S123 BST
Session IV: Young Investigators Seminars
12:30 p.m. Poster Viewing and Discussion Session BST Lobby
1:30 p.m. A simple model of nosocomial infection in the lung Krzystof Laudanski (Rochester, NY)
1:50 p.m. Alterations in antigen presentation by macrophages Steward Chang (Ann Arbor, MI)
during infection with M. Tuberculosis
2:10 p.m. Cooperativity in apoptosome formation might be important Elife Z Bagci (Pittsburgh, PA)
for the appropriate response of cell to apoptotic stimulus
2:30 p.m. Heart rate variability, approximate entropy, and exponent Vasiliios Papaioannou (Thessanoliki, Greece)
. analysis of HR signals of patients a multidisciplinary ICU
2:50 p.m. A reduced model of the immune response to endotoxin: Judy Day (Pittsburgh, PA)
a geometric approach
3:10 p.m. An explanation for the existence and variable severity Daniel Frattarell (Detroit, MI)
of adverse drug reactions
3:30 p.m. On the role of the macrophage biochemical network during Christian Ray (Ann Arbor, MI)
infection with M. Tuberculosis
3:50 p.m. Interaction of hemodynamics and fluid balance between Sven Zenker (NorthRhine Westfalia, Germany)
intravascular and interstitial compartments in septic shock
4:10 p.m. BioLogic: mathematical modeling of complex systems Rima Gandlin (Pittsburgh, PA)
4:30 p.m. Simulating changes in variability and complexity during Anton Burykin (Los Angeles, CA)
multiple organ dysfunction: a model of coupled stochastic
oscillators
4:50 p.m. Dynamics of HIV-1 infection in the lymph node during Seema Bajaria (Ann Arbor, MI)
5:10 p.m. Blood pressure variability in a murine model of sepsis Steven Hollenberg (Camden NJ)
5:50 p.m. ADJOURNMENT
7:00 p.m. Presenters and Chairpersons Dinner
TUESDAY, NOVEMBER 9
Session V: Specific Models of Complex Biomedical Systems
9:00 a.m. Dynamics of a Granulomatous Response Denise Kirschner
by M. tuberculosis
9:30 a.m. Modeling the Logic of Intra-Cellular Signaling Shlomo Ta’asan
10:00 a.m. Modular Concepts of Multi-Scale, Multi-Tissue Modeling Gary An
of Acute Inflammation
10:30 a.m. COFFEE BREAK
10:45 a.m. A Nephrologist’s Menagerie of Complex Systems John R. Hotchkiss
11:15 a.m. Bacterial Surface Carbohydrates and Host Survival in John G. Younger
a Biodistributive Model of Gram-Negative Bacteremia
11:45 a.m. In Silico Clinical Trial Design: Lessons and Directions Gilles Clermont
12:15 p.m. LUNCH Room S123BST
Session VI: Academia and Industry
1:00 p.m. Entrepreneurial Development of Discoveries Made Mitchell P. Fink
in an Academic Setting: Lessons Learned
1:30 p.m. Complexity and Industry: An Unlikely Marriage? Thomas Petzinger
2:00 p.m. The Marketplace of Diseases Associated with Steven Chang
Acute Inflammation
2:30 p.m. COFFEE BREAK
2:45 p.m. Mathematical Models in the Pharmaceutical Industry Billy W. Day
3:15 p.m. Data Mining of Complex Datasets Frederick D. Busche
3:45 p.m. New Optimization Techniques James Kraemer
4:15 p.m. The Biotech Marketplace – Reality Check 2004 Reed McManigle
4:45 p.m. Panel Discussion
5:15 p.m. ADJOURNMENT
Faculty Disclosure: In accordance with Accreditation Council for Continuing Medical Education requirements on disclosure, information about relationships of presenters with commercial interests (if any) will be included in materials distributed at the time of the conference.
Special Needs: Participation by all individuals is encouraged. Advance notification of any special needs will help us provide better service. Please notify us of your needs at least two weeks in advance of the program by calling Donna Kruse at 412-647-7980.